HTTP Client
1
Total requests
1
HTTP errors
Clients
http_client 1
Requests
| POST | https://api-free.deepl.com/v2/translate | |
|---|---|---|
| Request options | [ "headers" => [ "Authorization" => "DeepL-Auth-Key d1e89e57-c0b5-42df-bbe4-c71dfa4e14b9:fx" ] "json" => [ "text" => [ "BACKGROUND: Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relationship between radiographic and histopathological response remains unclear.METHODS: We retrospectively examined patients with initially unresectable HCC who received tyrosine kinase inhibitor (TKI) plus anti-programmed death 1 (PD-1) therapy before undergoing liver resection between March 2019 and September 2021 across 7 hospitals in China. Radiographic response was evaluated using mRECIST. A pCR was defined as no viable tumor cells in resected samples.RESULTS: We included 35 eligible patients, of whom 15 (42.9%) achieved pCR after systemic therapy. After a median follow-up of 13.2\u{A0}months, tumors recurred in 8 non-pCR and 1 pCR patient. Before resection, there were 6 complete responses, 24 partial responses, 4 stable disease cases, and 1 progressive disease case, per mRECIST. Predicting pCR by radiographic response yielded an area under the receiver operating characteristic curve (AUC) of 0.727 (95% CI: 0.558-0.902), with an optimal cutoff value of 80% reduction in the enhanced area in MRI (called major radiographic response), which had a 66.7% sensitivity, 85.0% specificity, and a 77.1% diagnostic accuracy. When radiographic response was combined with α-fetoprotein response, the AUC was 0.926 (95% CI: 0.785-0.999); the optimal cutoff value was 0.446, which had a 91.7% sensitivity, 84.6%, specificity, and an 88.0% diagnostic accuracy.CONCLUSIONS: In patients with unresectable HCC receiving combined TKI/anti-PD 1 therapy, major radiographic response alone or combined with α-fetoprotein response may predict pCR." ] "source_lang" => "EN" "target_lang" => "FR" ] "timeout" => 20 ] |
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| Response |
456
[ "info" => [ "header_size" => 368 "request_size" => 255 "total_time" => 0.138423 "namelookup_time" => 0.000392 "connect_time" => 0.037942 "pretransfer_time" => 0.080658 "size_upload" => 1825.0 "size_download" => 187.0 "speed_download" => 1355.0 "speed_upload" => 13224.0 "upload_content_length" => 1825.0 "starttransfer_time" => 0.080674 "primary_ip" => "194.124.204.71" "primary_port" => 443 "local_ip" => "185.176.225.12" "local_port" => 47492 "http_version" => 3 "protocol" => 2 "scheme" => "HTTPS" "appconnect_time_us" => 80571 "connect_time_us" => 37942 "namelookup_time_us" => 392 "pretransfer_time_us" => 80658 "starttransfer_time_us" => 80674 "total_time_us" => 138423 "effective_method" => "POST" "start_time" => 1792655449.2364 "original_url" => "https://api-free.deepl.com/v2/translate" "pause_handler" => Closure(float $duration) {#947 : "Symfony\Component\HttpClient\Response\CurlResponse" : { : CurlHandle {#927 …} : Symfony\Component\HttpClient\Internal\CurlClientState {#226 …} : -9223372036854775808 } } "debug" => """ * Trying 194.124.204.71:443...\n * Connected to api-free.deepl.com (194.124.204.71) port 443 (#0)\n * ALPN, offering h2\n * ALPN, offering http/1.1\n * successfully set certificate verify locations:\n * CAfile: /etc/ssl/certs/ca-certificates.crt\n * CApath: /etc/ssl/certs\n * SSL connection using TLSv1.3 / TLS_AES_256_GCM_SHA384\n * ALPN, server accepted to use h2\n * Server certificate:\n * subject: CN=*.deepl.com\n * start date: Sep 20 16:09:30 2026 GMT\n * expire date: Dec 19 16:09:29 2026 GMT\n * subjectAltName: host "api-free.deepl.com" matched cert's "*.deepl.com"\n * issuer: C=US; O=Let's Encrypt; CN=YE1\n * SSL certificate verify ok.\n * Using HTTP2, server supports multi-use\n * Connection state changed (HTTP/2 confirmed)\n * Copying HTTP/2 data in stream buffer to connection buffer after upgrade: len=0\n * Using Stream ID: 1 (easy handle 0x55b47af00c60)\n > POST /v2/translate HTTP/2\r\n Host: api-free.deepl.com\r\n authorization: DeepL-Auth-Key d1e89e57-c0b5-42df-bbe4-c71dfa4e14b9:fx\r\n content-type: application/json\r\n accept: */*\r\n user-agent: Symfony HttpClient (Curl)\r\n accept-encoding: gzip\r\n content-length: 1825\r\n \r\n * We are completely uploaded and fine\n * Connection state changed (MAX_CONCURRENT_STREAMS == 100)!\n < HTTP/2 456 \r\n < content-type: application/json; charset=utf-8\r\n < date: Thu, 22 Oct 2026 07:50:49 GMT\r\n < x-trace-id: 6375df3628334a2fa21a96f54ea41862\r\n < access-control-expose-headers: Server-Timing, X-Trace-ID\r\n < server-timing: l7_lb_tls;dur=42, l7_lb_idle;dur=0, l7_lb_receive;dur=0, l7_lb_total;dur=62\r\n < strict-transport-security: max-age=63072000; includeSubDomains; preload\r\n < \r\n """ ] "response_headers" => [ "HTTP/2 456 " "content-type: application/json; charset=utf-8" "date: Thu, 22 Oct 2026 07:50:49 GMT" "x-trace-id: 6375df3628334a2fa21a96f54ea41862" "access-control-expose-headers: Server-Timing, X-Trace-ID" "server-timing: l7_lb_tls;dur=42, l7_lb_idle;dur=0, l7_lb_receive;dur=0, l7_lb_total;dur=62" "strict-transport-security: max-age=63072000; includeSubDomains; preload" ] "response_content" => [ "{"message":"Quota exceeded. You\u0027ve used all the characters included in your free DeepL API plan. To continue translating, upgrade at https://www.deepl.com/your-account/subscription"}" ] ] |
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